Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia

• Status: Recruiting
• Trial end date: 2022-05-30
• Target enrollment: 0
• Participant gender: All

Summary

This is a prospective, randomized, single-blind trial evaluating prehospital patients experiencing moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5. Patients will be randomized to receive ketamine at or morphine by intravenous push.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nantes University Hospital
• Treatments: Ketamine; Morphine

Criteria

Inclusion Criteria:

• older than 18 years old

• prehospital moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5

Exclusion Criteria:

• unstable vital signs (systolic blood pressure <90 or >200 mm Hg, pulse rate <50 or >150 beats/min, and respiration rate <10 or >30 breaths/min)

• pregnancy

• breast-feeding

• altered mental status

• unable to give numeric rating scale scores

• allergy to morphine or ketamine

• acute pulmonary edema

• acute coronary syndrome

• renal or hepatic insufficiency

• patient who received morphine for the same acute pain

• acute psychiatric illness