Intravenous Tranexamic Acid Reducing Intraoperative Blood Loss in Huge Meningiomas Resection

• Status: Not yet recruiting
• Trial end date: 2025-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Intra-operative blood loss of huge meningioma resection patients on average was over 1000ml. Intra-operative massive hemorrhage was associated with longer hospital of stay, higher expense, and higher mortality. Previous studies indicated intra-operative tranexamic acid infusion would decrease blood loss for cardiac, trauma and obstetric procedures. However, limited researches focusing on the effect of tranexamic acid in neurosurgery population, with heterogenous pathologies. The purpose of this study was to investigate the effect of tranexamic acid on intra-operative blood loss in patients undergoing huge meningioma resection.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beijing Tiantan Hospital

Criteria

Inclusion Criteria:

• Patients undergoing selective meningioma resection with estimated tumor diameter >5cm on brain image.

• Age between 18-80 years.

• Obtain written informed consent.

Exclusion Criteria:

• Allergic to tranexamic acid.

• History of epilepsy.

• History of embolic or thrombotic disease..

• History of traumatic brain injury or neurosurgery.

• Receiving other anticoagulation or antiplatelet treatment.

• Severe hepatic or renal dysfunction.