Overview

Intravenous Versus Inhalational Anesthesia in Parkinson's Disease

Status:
Terminated

Trial end date:
2011-04-01

Target enrollment:
0

Participant gender:
All

Summary

Parkinson's disease is a common progressive degenerative disease affecting 3% of all patients over the age of 65. Given their age and frailty, these patients frequently require surgical procedures with general anesthesia. However, after surgery, patients with Parkinson's disease have longer hospital stays and a greater chance of not returning to independent living compared to age-matched controls (Berman MF, unpublished data). In part, this is due to a higher rate of post-operative delirium, which had an incidence of 60% in this population in one study. There is anecdotal evidence from neurologists specializing in movement disorder suggesting that there is also significant deterioration in parkinsonian motor symptoms and cognition lasting for months or years following surgery and anesthesia. The basis for this deterioration is unknown. We hypothesize that these problems are caused by particular medications used during inhaled anesthesia for surgical procedures.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Columbia University

Treatments:

Anesthetics
Isoflurane
Propofol
Remifentanil

Criteria

Inclusion Criteria:

- Clinical diagnosis of Parkinson's Disease with bilateral deep brain stimulation
surgery indicated as treatment

Exclusion Criteria:

- Not fluent in English