Intravenous Versus Intraperitoneal Instillation of Ondansetron for Decreasing Incidence of Nausea and Vomiting After Laparoscopic Gynecological Surgeries.

• Status: Not yet recruiting
• Trial end date: 2022-10-15
• Target enrollment: 0
• Participant gender: All

Summary

Study the effect of intraperitoneal instillation vs intravenous ondansetron on PONV added to intraperitoneal bupivacaine for enhanced recovery and to decrease incidence of PONV after laparoscopic surgeries.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zagazig University
• Treatments: Bupivacaine; Ondansetron

Criteria

Inclusion Criteria:

• Written informed consent from the patient.

• Age: 21-45 years old.

• Both sex.

• Physical status: ASA 1& II.

• BMI = (25-35 kg/m2).

• Type of operation: elective laparoscopic gynecological surgeries.

Exclusion Criteria:

• Altered mental state.

• Patients with known history of allergy to the study drugs.

• Advanced hepatic, renal, cardiovascular, and respiratory diseases.

• Patients with chronic pain received NSAID or opioid during previous two weeks.

• Patients with history of PONV or motion sickness and patients received antiemetic therapy 24 h before the surgery.