Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery

• Status: Completed
• Trial end date: 2017-07-27
• Target enrollment: 0
• Participant gender: Female

Summary

This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery. All patients will receive a standardized spinal anesthetic for operative anesthesia and will be randomized into one of three groups: (group 1) 1 gram IV acetaminophen every 8 hours for three doses, (group 2) 1 gram oral acetaminophen every 8 hours for three doses, or (group 3) no acetaminophen. This will be a randomized, open label study.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Medical University of South Carolina
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Parturients 18 years

• Elective Cesarean delivery

• Spinal anesthesia

• Able to consent to the study and participate in the follow-up.

Exclusion Criteria:

• Weight under 50 kgs

• Allergy to acetaminophen

• General anesthesia

• Urgent or emergent cases

• Bleeding diathesis or other coagulopathy

• G6PD deficiency

• Liver disease

• Substance abuse or dependence

• HELLP syndrome

• Thrombocytopenia or platelet dysfunction

• History or active gastrointestinal bleeding

• Acute kidney injury or chronic renal insufficiency

• Contraindication/refusal to spinal anesthesia

• Chronic pain

• Chronic narcotic use

• Illicit drug use

• Allergy to any study related medications.