Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty

• Status: Completed
• Trial end date: 2018-10-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if intravenous acetaminophen is superior to oral acetaminophen when used as part of a multimodal pathway for primary total hip arthroplasty.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Patients scheduled for elective, primary total hip replacement for osteoarthritis

• American Society of Anesthesiologists (ASA) Physical Classification I-III

• Weight 50 kg or greater

• Body mass index 18-40 kg/m2

Exclusion Criteria:

• Inability to consent to study

• Inability to speak English

• Pregnancy

• Weight <50 kg

• Revision hip replacement or emergency surgery

• Contraindications to spinal anesthesia: coagulopathy or bleeding diathesis, local infection, allergy to local anesthetics

• Allergies/intolerances/contraindications to any of the multimodal agents:

acetaminophen, pregabalin, celecoxib, ketamine, or dexamethasone

• Chronic pain from a separate source other than operative hip

• Daily opioid equivalent use of 30 mg of morphine or greater at time of consent

• History of heart failure

• History of drug or alcohol abuse

• Rheumatoid arthritis

• Uncontrolled anxiety, schizophrenia or other psychiatric disorder that, in the opinion of the investigator, may interfere with the study assessments

• Chronic malnutrition, renal or liver impairment

• Hypersensitivity to acetaminophen or any of its excipients