Intravenous n-3 Fatty Acids and Sudden Cardiac Death in Hemodialysis Patients

• Status: Completed
• Trial end date: 2007-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The main purpose of this study is to investigate whether intravenous infusion of a lipid emulsion with a high content of n-3 polyunsaturated fatty acids can improve heart rate variability and ventricular repolarization and reduce ventricular arrhythmias in hemodialysis patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aalborg Universitetshospital; Aalborg University Hospital

Criteria

Inclusion Criteria:

• Age > 18 yrs

• End-stage renal failure

• Maintenance haemodialysis treatment > 3 months

Exclusion Criteria:

• Allergy to fish or egg protein

• Body weight < 50 kgs

• Chronic supraventricular tachycardia

• Implanted pacemaker

• Myocardial infarction within 6 months

• PCI or CABG within 6 months

• Stroke or TIA within 6 months

• HbA1C > 10 %

• ALAT > 100 U/l

• Triglycerides > 3 mmol/l

• Ongoing infection

• Tendency to severe blood pressure drops during dialysis treatment

• Malignancy

• Psychiatric disorder

• Pregnancy