Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage
Status:
Unknown status
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
The proposed study is to evaluate the acceleration the clearance of intraventricular blood
(IVH) and subarachnoid hemorrhage (SAH) following ruptured intracranial aneurysms, thereby
ameliorating complications, such as cerebral vasospasm, hydrocephalus and intracranial
hypertension.
The primary objectives are:
1. Estimate the rate and variance of hematoma clearance following aneurysmal SAH, thereby
facilitating sample size determination for a subsequent larger study;
2. Assess the feasibility of a randomized controlled trial of intraventricular tissue
plasminogen activator (TPA) among patients with SAH (enrollment rate, ability to blind
investigators, protocol compliance);
3. Confirm the safety of intraventricular TPA.