Intravesical Antifibrinolytic for Patients With Hematuria and Clot Retention

• Status: Completed
• Trial end date: 2021-10-30
• Target enrollment: 0
• Participant gender: All

Summary

A study looking at the feasibility of doing a full-scale RCT that investigates the use of tranexamic acid intravesically prior to continuous bladder irrigation treatment in the emergency department for urinary retention due to clots.

We want to know:

• patient experience and acceptability of the intervention

• study procedures (recruitment, site appropriateness, staff engagement)

• safety data

• identify resource use

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fraser Health
• Collaborators: BC Support Unit; Michael Smith Foundation for Health Research
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• 18 years of age or older

• complaint of hematuria or urinary retention

• requiring CBI treatment

• able to consent to the study.

Exclusion Criteria:

• Pregnancy or breastfeeding

• Use of anticoagulants (warfarin, heparin, DOACs, etc.)

• known coagulopathy (genetic bleeding disorders, acquired deficiencies)

• urinary tract infection or pyelonephritis

• known hypersensitivity to TXA

• known renal failure

• known or history of thrombosis/thromboembolism (retinal vein/artery occlusion, deep vein thrombosis, pulmonary embolism)

• cognitive impairment rendering unable to provide informed consent and not having a substitute decision-maker present