Overview
Intravitreal Conbercept for Idiopathic Choroidal Neovascularization
Status:
Unknown status
Unknown status
Trial end date:
1969-12-31
1969-12-31
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this study is to evaluate the efficacy of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy as primary treatment for ICNV.Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Jiao Mingfei
Criteria
Inclusion Criteria:- Patient who give voluntary signed informed consent
- Patient affiliated with the Tianjin Medical University Eye Hospital or similar
- Patient with ICNV with active primary subfoveal, retrofoveal or juxtafoveal lesions
that affect the fovea as evidenced by angiography (fluorescein and/or indocyanin
green) and/or SD-OCT in the studied eye
- Patient willing, committed and able to return for all clinic visits and complete all
study-related procedures
Exclusion Criteria:
- Pregnant women
- Sexually active men or women of childbearing potential who are unwilling to practice
adequate contraception during the study
- Patient who is protected adults according to the terms of the law (French public
health laws)
- Involvement in another clinical trial (studied eye and/or the other eye)
- Patient with non-ICNV, especially:
- AMD
- High myopia defined as refraction ≥ - 6 diopters
- Other curative treatment of ICNV in the studied eye during the last 3 months before
the first intravitreal injection: anti-VEGF therapy, juxta- or extra-foveal macular
laser, photodynamic therapy, surgery, external radiotherapy, transpupillary
thermotherapy ...
- Medical history of retrofoveal focal macular laser photocoagulation in the studied eye
- Subretinal haemorrhage reaching the fovea centre, with a size > 50% of the lesion area
- Fibrosis or retrofoveal retinal atrophy in the studied eye
- Retinal pigment epithelial tear reaching the macula in the studied eye
- Medical history of intravitreal medical device in the studied eye
- Medical history of auto-immune or idiopathic uveitis
- Proved diabetic retinopathy
- Intra-ocular pressure ≥ 25 mmHg despite two topical hypotonic treatments
- Aphakia or lack of lens capsule (not removed by YAG laser) in the studied eye
- Arterial hypertension that is not controlled by an appropriate treatment
- Previous or actual treatment with systemic administration of anti-VEGF therapy
- Known hypersensitivity to aflibercept, or another drug composite of the medicinal
product used; allergy to fluorescein, indocyanin green, anaesthetic eye drops
- Active or suspected ocular or peri-ocular infection
- Serious active intra-ocular inflammation in the studied eye
- Medical history of intra-ocular surgery within 28 days before the first injection in
the studied eye
- Any illness or ocular condition that would require an intra-ocular surgery in the
studied eye within 12 months after the inclusion
- Follow up not possible during 12 months