Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to
it's apparent ability to counteract the renin-angiotensin system, which is frequently
overactive in many cardiovascular disease.
Two of the main actions of apelin are to increase the pumping ability of the heart and cause
blood vessels to relax. The investigators wish to assess if these actions are altered in the
setting of normal renin-angiotensin activation and increased renin-angiotensin activity.