Investigating the Central and Peripheral Mechanisms by Which Glucocorticoids Affect Hunger

• Status: Unknown status
• Trial end date: 2018-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine if glucocorticoids will change neural activation in regions of the corticolimbic-striatal system that regulate feeding.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yale University
• Treatments: Cortisol succinate; Glucocorticoids; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate

Criteria

Inclusion Criteria:

• BMI < = 26 kg/m2

• Ability to read and write English

Exclusion Criteria:

• Creatinine > 1.5

• Hgb < 10 mg/dL

• ALT > 2.5 x ULN

• Untreated thyroid disease

• Uncontrolled or severe hypertension

• Known neurological disorders

• Diabetes or impaired glucose tolerance

• Untreated or severe psychiatric disorders

• Malignancy

• Endogenous hypercortisolism

• Addison's disease

• Bleeding disorders

• Smoking

• Current or recent steroid use in the last 3 months

• Illicit drug use

• Eating disorders

• Drug or alcohol addiction

• History of claustrophobia

• Pregnancy

• Breastfeeding

• Contraindications to MRI

• Use of any psychoactive medication within the past 3 months