Investigating the Regulation of Reproductive Hormones in Adult Men

• Status: Completed
• Trial end date: 2007-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of the research study is to learn more about the regulation of reproductive hormones in adult men. We would like to understand what role testosterone and estradiol play in controlling the release of LH (lutenizing hormone) and FSH (follicle stimulating hormone). Testosterone and estradiol come from the testes, and LH and FSH are released from a gland in the head called the pituitary.

Men involved in the study will have detailed evaluations that involve overnight stays in the hospital and frequent blood sampling. The men in the study will also be receiving medications that affect the levels of various hormones in the body. This will allow the researchers to learn how various hormones influence each other. Men that participate in the study will receive medical evaluations and monetary compensation. Information gathered from this study will help in the development of new treatments for infertility and potentially new hormonal forms of contraception.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• Treatments: Hormones; Ketoconazole

Criteria

Inclusion Criteria:

• Men aged 18 to 50 years

• In good health

• On no medications

Exclusion Criteria:

Subjects will not be enrolled in this study if there is a history of:

• Liver disease or if screening blood tests demonstrate abnormal liver function tests

• Excessive alcohol consumption

• Illicit drug use

• Severe drug allergy

• Use of any concomitant medications

• Peptic ulcer disease or gastritis