Investigation Into the Role of GTN & RIPC in Cardiac Surgery

• Status: Completed
• Trial end date: 2019-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Glyceryl Trinitrate (GTN) reduces injury to the heart during heart-lung bypass surgery in combination with the newer technique of remote ischaemic preconditioning (RIPC).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University College, London
• Collaborator: University College London Hospitals
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• Age > 18 years all patients admitted for on- pump CABG and/or valve surgery

• Able to give consent

Exclusion Criteria:

• Allergies to excipients of IMP and placebo

• Chronic Renal failure (eGFR<30 ml/min/kg)

• Severe liver disease

• Peripheral arterial disease

• Pregnant or lactating women