Investigation Of Weight Loss And Body Composition Changes After Dosing With Either Placebo Or One Of Two Active Drugs

• Status: Completed
• Trial end date: 2007-06-07
• Target enrollment: 0
• Participant gender: All

Summary

The drugs GSK189075 and GW869682 result in increased caloric losses. This study is investigating how if taken over 8 weeks that affects weight loss, food intake and the composition of the body. The body composition (fat,water, lean mass) is determined using a new investigational MR technology.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: GlaxoSmithKline

Criteria

Inclusion criteria:

• BMI of 30 - 40kg/m

• Females may be included if they are surgically sterile or post-menopausal

Exclusion criteria:

• Change in body weight >4% in the last 3 months

• History of eating disorders

• had bariatric surgical intervention for obesity

• have type I or II diabetes

• Thyroid disorder not under control

• Renal or hepatobiliary disease

• Excessive alcohol consumption

• Use of drugs of abuse

• donated of blood in the last 3 months