Investigation of Novel Procedure for Methacholine Challenge Testing

• Status: Recruiting
• Trial end date: 0000-00-00
• Target enrollment: 15
• Participant gender: Both

Summary

The study will compare a novel volumetric method (performed with the Aerogen Solo vibrating mesh nebulizer) with the standard two-minute tidal breathing protocol (performed with the Wright jet nebulizer) for methacholine challenge testing. The results will then give an indication as to whether the novel technique accurately assesses a given dose of methacholine with the new Aerogen Solo device. In addition, the reproducibility of test results with each method will be examined. Altogether, the findings from this investigation may provide means for better standardization of current testing guidelines.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Saskatchewan
• Treatments: Methacholine Chloride
• Last Updated: 2016-11-14

Criteria

Inclusion Criteria:

• Men and women aged 18 or older

• Stable asthma

• Baseline methacholine PC20 less than or equal to 16mg/mL

• Baseline lung function equal or greater than 65% of predicted FEV1

Exclusion Criteria:

• Use of long-acting bronchodilators within 7 days of visit 1

• Pregnant or nursing women

• Cardiovascular problems

• Upper respiratory tract infection within 4 weeks of visit 1

• Allergy-induced asthma exacerbation within 4 weeks of visit 1