Investigation of Vascular Inflammation in Migraine Using Molecular Nano-imaging and Black Blood Imaging MRI

• Status: Unknown status
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

The investigators aim to investigate inflammation of cranial and meningeal arteries during pharmacologically induced migraine attacks, using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles and black blood imaging (BBI) MRI.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Danish Headache Center
• Treatments: Cilostazol; Ferrosoferric Oxide; Sumatriptan

Criteria

Inclusion Criteria:

• Written informed consent

• Subject has migraine without aura according to criteria of the International Headache Society (IHS)

• Subject has unilateral migraine 70% of the time

• Migraine can be pharmacologically provoked in the subject using cilostazol.

• Subject is on birth control

• Subject has no other medical history

Exclusion Criteria:

• Subject suffers from bilateral migraine

• Subject suffers from migraine with aura

• Subject suffers from other primary headaches as specified by IHS criteria

• Pregnant or breast feeding subjects

• Subjects with contraindications for undergoing MRI scans

• Any known drug allergy

• Any signs or disorders of iron overload, including but not limited to hemosiderosis and porphyria cutanea tarda