Investigation of a Combination Treatment of Escitalopram and rTMS

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

We intend to test in a randomized, rater blinded, placebo controlled, prospective study the primary hypothesis that an escitalopram-rTMS-combination treatment is more efficacious in the treatment of refractory major depression assessed with the Hamilton Depression Rating Scale

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Charite University, Berlin, Germany
• Collaborator: H. Lundbeck A/S
• Treatments: Citalopram; Dexetimide

Criteria

Inclusion Criteria:

• Major Depressive Episode (according to DSM IV standards)

• HAMD > 20

• Patient has an IQ > 70 based on the investigator´s judgement

• Patient is male or nonpregnant female adequately protected from conception

• Patient is able to comply with all testing and follow-up visit requirements defined by the study protocol

• Patient has voluntarily signed an informed consent in accordance with institutional policies

Exclusion Criteria:

• Patient has a history of schizophrenia, schizoaffective disorder or delusional disorder

• Patient currently has a secondary diagnosis of, or signs of, delirium, dementia, amnestic or other cognitive disorder per DSM IV

• Patient is suicidal

• Patient has had an alcohol or substance dependence within the previous 12 month

• Patient is currently enrolled in another investigational study

• Patient has a history of, or evidence of, significant central nervous disease (especially seizures)

• Patient has previously been treated with escitalopram

• Contraindication against escitalopram or rTMS