Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease

• Status: Completed
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Although nasal polyposis has been recognized as an inflammatory process for many years, the true etiology of nasal polyposis mainly unknown. Despite surgical removal, the recurrence rate after surgery has been reported as high as 87% within the first year after surgery. Anecdotally the Principal Investigator found an incidence of pH probe-proven laryngopharyngeal reflux approaching 80% in his patients with nasal polyposis. Although his number of cases was small, the incidence of recurrence of polyps in these patients was 17%.

The PI believes that such an association is too great to be explained by chance alone, and deserves further study. He anticipates two contributions to the literature from this study, the first documenting the incidence of extraesophageal (laryngopharyngeal) reflux in patients with polyposis, and the second showing the impact of reflux treatment on the recurrence rate of the polyps, initially after one year of therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Head and Neck Surgery Associates
• Treatments: Dexlansoprazole; Lansoprazole

Criteria

Inclusion Criteria:

Subjects will:

• Be adults with nasal polyposis

• recruited from the PI's private practice

• Not be currently taking a PPI

• Be able and willing to undergo a noninvasive 24 hour pH probe study; and

• Take a PPI.

Exclusion Criteria:

Patients who:

• Are pregnant

• Have a history of surgical treatment for reflux disease

• History of allergic or adverse reaction to Prevacid or adverse reaction to Prevacid during the study period; and

• Do not meet inclusion criteria.