Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease
Status:
Completed
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
Although nasal polyposis has been recognized as an inflammatory process for many years, the
true etiology of nasal polyposis mainly unknown. Despite surgical removal, the recurrence
rate after surgery has been reported as high as 87% within the first year after surgery.
Anecdotally the Principal Investigator found an incidence of pH probe-proven
laryngopharyngeal reflux approaching 80% in his patients with nasal polyposis. Although his
number of cases was small, the incidence of recurrence of polyps in these patients was 17%.
The PI believes that such an association is too great to be explained by chance alone, and
deserves further study. He anticipates two contributions to the literature from this study,
the first documenting the incidence of extraesophageal (laryngopharyngeal) reflux in patients
with polyposis, and the second showing the impact of reflux treatment on the recurrence rate
of the polyps, initially after one year of therapy.