Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women

• Status: Recruiting
• Trial end date: 2025-10-16
• Target enrollment: 0
• Participant gender: All

Summary

There is significant evidence outlining the importance of inflammation in the pathogenesis of coronary artery disease. Important differences exist between sexes in incidence, disease patterns and outcomes in coronary artery disease that is not well understood. It is likely that key differences in the underlying biological mechanism, in particular in inflammatory responses, play a part in underpinning these differences. Previous evidence demonstrates that healthy females appear to be more adept at resolving inflammation compared to healthy males. Since inflammation is thought to be a key initiating phenomenon in coronary artery disease the investigators will examine the differences in inflammatory resolution between the sexes in healthy volunteers.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Queen Mary University of London
• Treatments: Cantharidin

Criteria

Inclusion Criteria:

1. Healthy male and female volunteers

2. Aged 18-45

3. Volunteers who are willing to sign the consent form

Exclusion Criteria:

1. Healthy subjects unwilling to consent

2. Pregnant, or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result

3. Current breast feeding

4. History of any serious illnesses, including recent infections or trauma

5. Subjects taking systemic medication (other than the oral contraceptive pill)

6. Subjects with recent (2 weeks) or current antibiotic use

7. Subjects with any history of a blood-borne infectious disease such as Hepatitis B or C virus, or HIV