Investigation of the Effect of N Acetylcysteine Against Anti-Tuberculosis Drugs Induced Liver Toxicity
Status:
Completed
Trial end date:
2009-04-01
Target enrollment:
Participant gender:
Summary
Tuberculosis is one of the major health problems in developing countries. Isoniazid, rifampin
and pyrazinamide, the first line drugs used for tuberculosis chemotherapy, are associated
with hepatotoxicity. The rate of hepatotoxicity has been reported to be much higher in
developing countries compared to that in advanced countries with a similar dose schedule.
Oxidative stress has proposed as one of the mechanisms responsible for anti-tuberculosis
drugs induced hepatic injury. The oxidative stress is closely associated with decrease of
glutathione levels. In the present study N acetylcysteine, a precursor of glutathione, was
investigated for hepatoprotective effect against anti-tuberculosis drugs induced liver
injury.
Phase:
N/A
Details
Lead Sponsor:
National Research Institute of Tuberculosis and Lung Disease, Iran