Investigation of the Influence of Gender on Cardiovascular Function

• Status: Completed
• Trial end date: 2017-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Inflammation is a key initiating and damaging factor in many illnesses including infection, arthritis and cancer but also of particular relevance to this study in diseases of the heart and blood vessels (i.e. cardiovascular disease). Much evidence now exists demonstrating that male sex increases ones risk of cardiovascular disease. More recent evidence demonstrates that inflammatory responses in females appear to dampened in comparison to age matched males. Since inflammation is thought to be a key initiating phenomenon in many cardiovascular disease states the investigators will examine the differences in acute inflammatory responses between the sexes in healthy volunteers and the impact this has on the function of blood vessels.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Queen Mary University of London
• Treatments: Cantharidin; Vaccines

Criteria

Inclusion Criteria:

Healthy subjects aged 18-45 who have volunteered themselves and are willing to sign the consent form.

Exclusion Criteria:

1. Healthy subjects unwilling to consent

2. History of hypertension, diabetes or hypertensive on BP measurement

3. Pregnant, or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result

4. History of any serious illnesses, including recent infections or trauma

5. Subjects taking systemic medication (other than the oral contraceptive pill)

6. Subjects with self-reported use of mouthwash or tongue scrapes

7. Subjects with recent or current antibiotic use

8. Subjects with a history, or recent treatment of (within last 3 months) of any oral condition (excluding caries), including gingivitis, periodontitis and halitosis.

9. Subjects that have recently participated (preceding 3 months) in any clinical studies involving administration of an inflammogen.