Investigation of the Strategy of Preventing Post-operative Opioid-induced Hyperalgesia

• Status: Unknown status
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

The concept of Enhanced Recovery After Surgery(ERAS) has been prevalent in recent years. In the ERAS guideline, short-acting anesthetics, instead of long-acting opioid anesthetics, were recommended during surgery to decrease post-operative complication and length of hospital stay. Propofol-remifentanil based total intravenous anesthesia (TIVA) can provide quicker emergence and decreased post-operative nausea and vomiting. However, the prescription of opioid (especially remifentanil) may induce opioid-induced hyperalgesia (OIH) and increase the requirement of analgesics. Previous studies provided some strategies to prevent OIH. The purpose of this study is to investigate the effect of adding remifentanil(1 mcg/kg) after emergence and endotracheal extubation in breast cancer females receiving breast surgery under propofol-remifentanil based TIVA for the prevention of OIH.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tri-Service General Hospital
• Treatments: Analgesics, Opioid; Remifentanil

Criteria

Inclusion Criteria:

• Subject's ASA (American Society of Anesthesiologists) Physical Status Classification:

I (A normal healthy patient)~III(A patient with severe systemic disease)

• Subject has breast cancer and scheduled for breast surgery using total-intravenous anesthesia(TIVA)

Exclusion Criteria:

• Subject's ASA (American Society of Anesthesiologists) Physical Status Classification >3

• Subject doesn't receive total-intravenous anesthesia(TIVA) during surgery

• Subject has psychiatric disease

• allergic to opioid or propofol

• History of alcoholism

• History of drug abuse