Involvement of Reticulum Endoplasmic Stress in the Physiopathology of Polycystic Ovary Syndrome

• Status: Completed
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The main objective of the present project is to evaluate the relevance of reticulum stress in the pathogenesis of polycystic ovary syndrome (PCOS), focusing particularly on the underlying mechanisms of insulin resistance, which is the origin of metabolic comorbidities. Furthermore, the investigators will assess the potential of insulin sensitizers as a treatment to control endoplasmic reticulum stress markers in PCOS patients.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
• Treatments: Folic Acid; Inositol; Metformin; Vitamin B Complex

Criteria

Inclusion Criteria:

• Women diagnosed with PCOS using the Rotterdam criteria

• Women of reproductive age

Exclusion Criteria:

• Organic, malignant, haematological, infectious or inflammatory disease

• History of ischaemic heart disease (stroke or thromboembolism)

• Diabetes mellitus,

• Secondary causes of obesity (hypothyroidism, Cushing's syndrome)

• Severe hypertension.

• Smoking or alcohol habit