Irbesartan and Atenolol in Hypertensive Heart Disease
Status:
Completed
Trial end date:
1997-04-01
Target enrollment:
Participant gender:
Summary
The renin-angiotensin-aldosterone system has been implicated in the control of structural
changes of the heart and the vasculature, beyond the effects on blood pressure.
This projects examines the importance of the renin-angiotensin-aldosterone system and the
sympathetic nervous system in the control of cardiac and vascular structure and function in
subjects with hypertension.Patients with hypertension and left ventricular hypertrophy were
randomized to an angiotensin receptor blocker or a beta adrenergic receptor blocker for 48
weeks. Repeat investigations of blood pressure, structure and function of the heart and the
vascular tree, and neurohormones were performed. Two control groups, consisting of
normotensive subjects and of hypertensive subjects with no cardiac hypertrophy were also
examined for comparison.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Karolinska Institutet
Collaborators:
Bristol-Myers Squibb Sanofi Swedish Heart Lung Foundation