Irinotecan, Cetuximab and Everolimus to Patients With Metastatic Colorectal Cancer

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This is an open, multicenter phase II trial of therapy with a combination of cetuximab, and irinotecan every second week combined with a daily dose of everolimus to patients with metastatic colorectal cancer with Kirsten rat sarcoma viral oncogene (KRAS) mutation or to patients resistent to cetuximab and irinotecan therapy for metastatic colorectal cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Herlev Hospital
• Collaborators: Aalborg Universitetshospital; Aalborg University Hospital; Odense University Hospital
• Treatments: Camptothecin; Cetuximab; Everolimus; Irinotecan; Sirolimus

Criteria

Criteria for inclusion:

• Patients with a histological or cytological verified adenocarcinoma of the colon or rectum with non-resectable or metastatic cancer.

• Patients with measurable disease without previous radiotherapy

• Patients with metastatic colorectal cancer with progression after previous therapy with 5-fluoropyrimidines, oxaliplatin or irinotecan. Patients should have been treated with oxaliplatin, but if oxaliplatin has be contraindicated or not tolerated the patient can participate in the trial.

• Patients with KRAS-mutation in their primary tumour or metastasis.

• Patients with progression after therapy with irinotecan or cetuximab independent of KRAS mutation status.

• Previous radiotherapy is allowed to less than 25 % of the bone marrow.

• Age more or equal to 18 years.

• Performance status less than 3.

• An expected survival time of at least 3 months.

• Signed informed consent according to specifications from the ethical comites.

Criteria for exclusion:

• Former or other concurrent malignant disease except treated basal cell carcinoma or in situ cervical cancer.

• No cytotoxic therapy or other experimental treatment within 28 days before inclusion.

• No former therapy with everolimus or other rapamycin as sirolimus or temsirolimus.

• No known hypersensitivity for one or more components in the therapy.

• No uncontrolled diabetes

• No serious non-healing wounds, gastric ulcers, bone fractures, greater surgical procedures, major traumatic injuries within 28 days before inclusion.

• No ongoing bleeding or pathological condition associated with a risk of bleeding.

• No liver disease as cirrhose, chronical active hepatitis or chronic persistent hepatitis.

• No gastrointestinal disturbances in function that might cause a major change in the absorption of everolimus as ulcerative disease, uncontrolled nausea, vomiting, diarrhoea, malabsorption syndrome.

• No planned immunisation with attenuated virus in the study period.

• Patients that is unable to follow treatment or evaluation plan.

• Every condition or therapy that after the judgement of investigator might infer the patient a risk or influence the trials objective.

• Pregnant or breastfeeding women.

• At fertile women this is insured by a negative test of pregnancy or use of a safe anticonception during the trial period and at least 3 months after end of treatment.

• Patients with active infections or other serious medical co-morbidity, that might prevent the patient from being treated with the protocoled therapy.

• Incapacitated