Iron Repletion in Chronic Cough and Iron Deficiency

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

Chronic cough is more frequent and severe in women than in men. Women often have decreased iron stores, due to menses and pregnancies. Aim of the study: to investigate if iron deficiency has a role in chronic cough by favouring airway hypersensitivity to inhaled irritants.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Turin, Italy
• Collaborator: Regione Piemonte
• Treatments: Histamine; Iron; Loratadine; Omeprazole; Proton Pump Inhibitors

Criteria

Inclusion Criteria:

• Unexplained cough : no detectable trigger for chronic cough identified, such as persistent rhinitis, chronic sinusitis, gastroesophageal reflux disease and asthma.

• no benefit by prior treatment with antiH1-histaminic drug and proton pump inhibitor.

• iron deficiency.

• normal lung function tests and chest radiography no relevant systemic disease.

• no acute respiratory infection in the last eight weeks.

• no pharmacological treatment in the last two weeks.

Exclusion Criteria: