Iron Status and Human Metabolism

• Status: Completed
• Trial end date: 2016-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Iron deficiency is common in cardiorespiratory diseases and appears to contribute to a worse outcome. This human physiology study will examine the extent to which human skeletal muscle metabolism and exercise physiology are impaired by iron deficiency.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oxford
• Collaborators: British Heart Foundation; National Institute for Health Research, United Kingdom
• Treatments: Ferric Compounds; Iron

Criteria

Inclusion Criteria:

• Willing and able to give informed consent for participation in the study

• Men and women aged 18 years or older and generally in good health

• For iron-deficient volunteers: ferritin ≤ 15 microg/L and transferrin saturation < 16%

• For iron-replete volunteers: ferritin ≥ 20 microg/L and transferrin saturation ≥ 20%

Exclusion Criteria:

• Haemoglobin < 8.0 g/dL

• Haemoglobinopathy

• Iron overload, defined as ferritin > 300 microg/L

• Hypoxaemia (SpO2 < 94%) or significant co-morbidity that may affect haematinics, metabolic or ventilatory responses

• Iron supplementation or blood transfusion within the previous 6 weeks

• Pregnancy or breast feeding

• Inability to exercise isolated calf muscle using a pedal or on a bicycle ergometer

• Contraindication to magnetic resonance spectroscopy exposure such as metallic implant

• Contraindication to receiving intravenous ferric carboxymaltose