Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents

• Status: Recruiting
• Trial end date: 2024-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will examine if brain insulin resistance is a feature of major depressive disorder (MDD) in humans using magnetic resonance imaging (MRI) measures sensitive to brain insulin action. This study will examine adolescents, as MDD onset commonly occurs during this age, and the impacts of cumulative medication exposure and other lifestyle-related confounds are also lower in this age group, improving our ability to understand the underlying biology.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centre for Addiction and Mental Health
• Treatments: Insulin Lispro

Criteria

Inclusion Criteria:

• Age 14- 18

• MDD diagnosis (MDD group subjects)

• Medication-naive or free (>3 months off antidepressants/ other psychotropic)

• BMI between 18.5 and 24.9 kg/m^2

• Right handed

Exclusion Criteria:

• History of primary psychotic illness

• History of current substance use disorder

• Pre-diabetes or diabetes

• First degree relative with diabetes

• Use of weight, lipids, or blood pressure reducing agents

• History of liver disease

• MRI contraindications

• Positive pregnancy test

• Allergic to exogenous insulin