Is Spontaneous Bacterial Peritonitis Still Responding to 3rd Generation Cephalosporins?

• Status: Unknown status
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Current European and most other international guidelines recommend the use of a third-generation cephalosporin as the first choice, or amoxicillin-clavulanate acid or fluoroquinolones as an alternative choice .

These recommendations are based mainly on clinical trials that were very often conducted a decade or more ago, and on the assumption that E. coli would be involved in nearly half of the cases.

The microbial etiology of SBP remains relatively constant; however, the antibiotic resistance rate especially for third-generation cephalosporins (including cefotaxime and ceftazidime), ciprofloxacin, and ofloxacin increased dramatically .

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tanta University
• Treatments: Cefotaxime; Cefoxitin; Ceftriaxone; Cephalosporins

Criteria

Inclusion Criteria:

• Liver cirrhosis with ascites and SBP

Exclusion Criteria:

• ascitic fluid with polymicrobial infections