Ischaemia-réperfusion During the Coronary Surgery With Beating Heart

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Less oxidative stress occurs during off-pump than on-pump coronary artery bypass graft (CABG) surgery but warm ischaemia-reperfusion injury may occur following transient coronary artery clamping. The aim of this study was to compare the preventive effects of diltiazem and N-acetylcysteine (NAC), alone or in combination, on biomarkers of myocardial damage and oxidative stress during off-pump CABG surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Strasbourg, France
• Treatments: Diltiazem; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Age included between 60 and 80 years

Exclusion Criteria:

• Age < 60 or > 80 years

• Pregnancy

• The allergy in used medicines (N-acétylcystéine, Diltiazem)

• Presence of a pathology valvulaire associated

• Urgency

• Unstable angor

• Bypass as a matter of urgency

• Recours peropératoire to a CEC

• FE < 0,40

• BAV of the 2nd and 3rd not sailed degree

• fibrillation or flutter little finger.