Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins

• Status: Completed
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and then a re-establishment of flow. The blood vessel lining plays a key role in this injury. This research will examine, in human volunteers, several important modifiers of APC in human blood vessels: high blood sugar, vitamin C, and statin drugs. Thus, the proposed studies will advance the investigators' understanding of mechanisms of this injury in humans and explore important modifiers of APC protection from injury.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: US Department of Veterans Affairs; VA Office of Research and Development
• Treatments: Ascorbic Acid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Sevoflurane; Simvastatin; Vitamins

Criteria

Inclusion Criteria:

• Young, healthy volunteers, 18-35 yr of age;

• Females will be studied at the same phase of their estrous cycle in each protocol.

Exclusion Criteria:

• Beta-blocker therapy or any medication that might interfere with vascular responses;

• Pregnant or lactating women;

• Substance abusers;

• Smokers;

• Anyone with cardiovascular, renal, or other systemic disease including hypertension and/or diabetes;

• Also excluded are volunteers with family history of malignant hyperthermia, or significant gastro-esophageal reflux.