Ischemic Injury and Ischemic Preconditioning in Diabetes

• Status: Completed
• Trial end date: 2005-05-01
• Target enrollment: 0
• Participant gender: All

Summary

In this proof-of-concept study, forearm vulnerability to ischemic exercise is studied in patients with type 1 diabetes mellitus with and without prior ischemic preconditioning (short period of ischemia that protects against subsequent ischemic exercise). Annexin A5 scintigraphy is used to quantify subtle signs of mild and reversible forearm injury that results from ischemic exercise.

The following hypotheses are tested:

1. Patients with type 1 diabetes are not more vulnerable to ischemic injury as compared with previously studied healthy volunteers.

2. Ischemic preconidtioning is still present in patients with type 1 diabetes. Depending on the validity of hypothesis 2, the effect of short pharmacological interventions are studied on vulnerability to forearm ischemia/reperfusion injury in the absence or presence of local forearm ischemic preconditioning.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University
• Collaborator: Dutch Diabetes Fund
• Treatments: Adenosine; Annexin A5; Diazoxide; Glyburide

Criteria

Inclusion Criteria:

• type 1 diabetes mellitus

• age 18-50 years

Exclusion Criteria:

• hypertension (systolic blood pressure > 140 mmHg and/or diastolic blood pressure > 90 mmHg

• cardiovascular disease (coronary artery insufficiency,CVA/TIA, peripheral artery disease

• HbA1c > 9%

• Body Mass Index < 25 kg/m2

• Unable to stop co-medication (other than insulin) for 1 week

• Previous exposure to radiation (diagnostic or therapeutic) in the past year