The purpose of this study is to test the safety and efficacy of islet cell transplants for
the treatment of type 1 diabetes mellitus. It has been shown that normal control of blood
sugar levels can prevent progression of complications (such as kidney disease, nerve damage,
and vascular disease) from diabetes. This research study is designed to see if normal blood
sugar control can be achieved by transplanting pancreatic islet cells into your liver, which
may reduce or eliminate your need for insulin. Patients may qualify to participate in this
research study if they have type 1 diabetes mellitus for at least five years and meet at
least one of the following criteria:
- Experience hypoglycemic unawareness - Defined as inability to tell when blood glucose is
low (for example, may not feel symptoms such as shaking, sweating, and rapid heartbeat
that usually signify that glucose is low)
- Have been hospitalized several times in the past year for low blood sugar and/or high
blood sugar
- Have complications of diabetes such as retinopathy, kidney problems, or neuropathy