Islet of Langerhans Graft Monitoring by Magnetic Resonance Imaging

• Status: Terminated
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of this pilot study is to assess the feasibility and safety of ex vivo islet labelling prior to intraportal transplantation in patients with type 1 diabetes with the purpose of islet graft imaging. The secondary objective is to determine the usefulness of this method for long-term islet graft monitoring.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Geneva

Criteria

Inclusion Criteria:

• All patients on the waiting list for an islet of Langerhans transplantation procedure

Exclusion Criteria:

• Allergy to ferucarbotran

• Inability to undergo MRI (patients carrying osteosynthesis material, pacemakers or other metallic devices)

• Claustrophobia (tolerance to MRI)

• Hemosiderosis/hemochromatosis (interference with MRI signal)