Isolated Hepatic Perfusion in Combination With Ipilimumab and Nivolumab in Patients With Uveal Melanoma Metastases
Status:
Recruiting
Trial end date:
2023-06-01
Target enrollment:
Participant gender:
Summary
Uveal melanoma is the most common primary intraocular malignancy in adults. Despite
successful control of the primary tumour, metastatic disease will develop in approximately
35%-50% of the patients within 10 years. The liver is the most common site for metastases,
and about 50% of the patients will have isolated liver metastases. Isolated hepatic perfusion
is a regional treatment where the liver is completely isolated from the systemic circulation,
allowing a high concentration of chemotherapy to be perfused through the liver with minimal
systemic exposure. The introduction of modern immunotherapy in the treatment arsenal for
cutaneous melanoma also creates hope for patients with uveal melanoma metastases. However,
the results of immunotherapy have so far been disappointing. The reason for the low efficacy
could be that uveal melanoma develops in the immune privileged eye.
The hypothesis in this trial is that isolated hepatic perfusion with melphalan causes an
immunogenic type of cell death by local tumour destruction while leaving the immune-system
intact. This will cause an activation of the immune-system and the addition of ipilimumab and
nivolumab will enhance this effect, ultimately increasing the treatment efficacy.
The primary objective of this trial is to evaluate the safety and tolerability of isolated
hepatic perfusion together with ipilimumab and nivolumab when given at the same time or as a
sequenced regimen. The study design is a phase I randomized controlled, multicentre,
open-label trial. Active follow-up will be performed for 2 years. Patients will be randomized
after diagnoses of metastatic disease to one of the following treatment arms:
Arm A. Patients will be treated with IHP followed by 4 courses of ipilimumab 3mg/kg and
nivolumab 1mg/kg every third week followed by continued nivolumab 480mg q4w up to 1 year.
Arm B. Patients will be treated with 1 course of ipilimumab 3mg/kg and nivolumab 1mg/kg
followed by IHP after 3 weeks and then another 3 courses of ipilimumab 3mg/kg and nivolumab
1mg/kg every third week followed by continued nivolumab 480mg q4w up to 1 year.