Isolated and Associated Effects of Physical Exercise and Estrogen Therapy on Climactercs Women
Status:
Completed
Trial end date:
2009-02-01
Target enrollment:
Participant gender:
Summary
This study will investigate the isolated and the associated effect of estrogen therapy and
physical exercise in the function, regulation and cardiovascular risk markers of 60
postmenopausal women, (45 - 60 years old). The volunteers will be randomaized into two
groups: estrogen therapy (estradiol valerate 1 mg/day oraly) and placebo. The two groups will
be randomaized into two subgroups: exercise group (aerobic trainning,cicle-ergometre, 50
minutes, 3 x week) and sedentary group. At 0, 6 and 12 months the volunteers will be submited
to: clinical analise, cardiorespiratory analise (ergoepirometric test), quality of life
questionare (Short Form-36 [SF-36]), ambulatory blood pressure monitoring during 24 hours and
to 2 experimental sessions where the cardiovascular responses to insulin action
(euglicemic/hiperinsulinemic clamp) and to physical and mental stress (microneurography) will
be accessed. Besides these, the volunteers of the sedentary group will be submited to an
extra session at 6 months of study evaluate the physiological answer to insulin infusion
after an acute session of exercise.
Phase:
N/A
Details
Lead Sponsor:
University of Sao Paulo General Hospital
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo