Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department

• Status: Completed
• Trial end date: 2017-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will compare the efficacy of isopropyl alcohol and conventional anti-emetics with three study arms: (1) inhaled isopropyl alcohol plus oral ondansetron; (2) inhaled isopropyl alcohol plus oral placebo; (3) inhaled placebo plus oral ondansetron.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brooke Army Medical Center
• Treatments: Ethanol; Ondansetron

Criteria

Inclusion Criteria:

• ages 18 and older

• complaint of nausea and/or vomiting reported at 3 or above on verbal numerical rating scale at the time of triage

Exclusion Criteria:

• allergy to isopropyl alcohol or ondansetron

• inability to breathe through nose (e.g., recent upper respiratory infection)

• intake of cefoperazone, disulfiram, or metronidazole within the last 24 hours

• mental status precluding informed consent including intoxication

• known QT-prolongation

• clinical suspicion for serotonin syndrome

• intravenous catheter in place prior to study start

• medications administered since patient arrival (e.g., in triage)