Itopride as an Adjuvant for Bowel Preparation in Patients With Chronic Constipation is Effective
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Bowel preparation is a major determinant of colonoscopy and colorectal surgery. Polyethylene
glycol electrolyte solutions (PEG-E) are the most commonly used laxatives in China. However,
a significant number of patients, especially those constipated patients, failed colonoscopies
due to poor bowel cleaning. Inadequate preparation may also lead to missed colonic lesions.
The study is based on the hypothesis: itopride hydrochloride, a prokinetic agent, its dual
role as dopamine D2 receptor antagonism and acetylcho-linesterase inhibition make it an
appropriate adjuvant for bowel preparation. It was reported to promote colonic peristalsis,
shorten colonic transit time and accelerate propulsion of colonic luminal contents through
inhibition of M3 receptor and dopamine D2 receptors in vitro and in vivo. So this study is to
determine the efficacy, tolerance and safety of high dose of itopride, when given in
different times before administration of PEG-E, for colonic preparation in patients with
chronic constipation.