Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps

• Status: Terminated
• Trial end date: 2019-05-15
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this randomized controlled double-blinded trial is to determine if the addition of an oral antifungal to typical post-operative medical therapy can prevent or reduce the incidence of recurrence of nasal polyps in fungal sensitive patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Treatments: Hydroxyitraconazole; Itraconazole

Criteria

Inclusion Criteria:

• Meet criteria for diagnosis of CRS with nasal polyps undergoing medically indicated sinus surgery

Exclusion Criteria:

• cystic fibrosis

• aspirin exacerbated respiratory disease

• uncontrolled or unstable chronic diseases such as uncontrolled diabetes

• active or history of cancer

• HIV positive

• history of liver or kidney disease

• history of disease with effects on immune system

• pregnant

• allergy to triazole antifungals