Ixabepilone and Vorinostat in Treating Patients With Metastatic Breast Cancer
Status:
Completed
Trial end date:
2019-09-27
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as ixabepilone, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing or
by stopping them from spreading. Vorinostat may stop the growth of tumor cells by blocking
some of the enzymes needed for cell growth. Giving ixabepilone together with vorinostat may
kill more tumor cells.
PURPOSE: This randomized phase I trial is studying the side effects, best way to give, and
best dose of vorinostat when given together with ixabepilone in treating patients with breast
cancer that has spread to another place in the body.