Overview

Janus Kinase Inhibition in Granuloma Annulare

Status:
Not yet recruiting
Trial end date:
2025-02-01
Target enrollment:
Participant gender:
Summary
The primary objective is to determine if JAK1 specific inhibition is effective in treating granuloma annulare (GA), a problematic inflammatory skin disease without an FDA approved treatment. The primary outcome will be the percentage change in the body surface area (BSA) involvement by GA after 6 months of treatment with abrocitinib 200 mg daily in 10 patients with moderate to severe GA affecting at least 5% body surface area (BSA).
Phase:
Phase 2
Details
Lead Sponsor:
William Damsky
Collaborators:
Pfizer
Yale University
Treatments:
Abrocitinib