Japan-Working Groups of Acute Myocardial Infarction for the Reduction of Necrotic Damage by ANP

• Status: Completed
• Trial end date: 2005-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate whether ANP as an adjunctive therapy for AMI reduces myocardial infarct size and improves regional wall motion.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cerebral and Cardiovascular Center
• Collaborator: Japan Cardiovascular Research Foundation

Criteria

Inclusion Criteria:

1. Age 20-79 years

2. Chest pain of more than 30 min

3. 0.1 mV ST-segment elevation in 2 contiguous ECG leads

4. Admission to hospital within 12 h of symptom onset

5. First episode of AMI

6. Candidates for PCI

Exclusion Criteria:

1. History of old myocardial infarction

2. Left main coronary artery stenosis

3. Severe liver and/or kidney dysfunction

4. Suspected aortic dissection

5. History of coronary artery bypass graft

6. History of allergic response to drugs

7. Severe hypovolemia

8. Right ventricular infarction