KULeuven Intensive Insulin Therapy Study in Medical Intensive Care Patients
Status:
Completed
Trial end date:
2005-06-01
Target enrollment:
Participant gender:
Summary
In a previous study, we showed that tight blood glucose control with insulin during intensive
care reduced morbidity and mortality of surgical intensive care patients. Whether this
intervention also improves prognosis of medical intensive care patients remains unknown. The
current prospective, randomized, controlled study will assess the impact of intensive insulin
therapy on the outcome of patients in a medical intensive care unit. On admission, patients
will be randomly assigned to either strict normalization of blood glucose (80-110 mg/dl) with
intensive insulin therapy or the conventional approach, in which insulin infusion is
initiated only when blood glucose exceeds 215 mg/dl, to maintain blood glucose levels between
180 and 200 mg/dl.
Phase:
Phase 2
Details
Lead Sponsor:
Katholieke Universiteit Leuven KU Leuven
Collaborators:
Fund for Scientific Research, Flanders, Belgium Novo Nordisk A/S