Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism
Status:
Completed
Trial end date:
2005-12-01
Target enrollment:
Participant gender:
Summary
The tissue kallikrein-kinin (KKS) and renin-angiotension-aldosterone system (RAAS) had been
implicated in regulating blood pressure and electrolyte homeostasis. Both of the KKS and RAAS
may work coordinately to regulate salt metabolism, local blood flow. Thus, we conducted this
study to elucidate, first, whether some alterations in components of the kallikrein-kinin
system could do effect on aldosterone secretion.
Previous study has shown the post captopril plasma aldosterone concentration (PAC)/ plasma
rennin activity (PRA) ration (ARR) was a reliable method for diagnosis of primary
aldosteronism (PA). The ARR change by angiotensin II receptor blockade was reported to be
significantly higher than that by ACE inhibitor. This study assessed whether angiotensin II
receptor blockade offers any additional advantage in the diagnosis of PA. Clinically we
evaluated the sensitivity and specificity of captopril (angiotensin-converting enzyme
inhibition) and losartan (angiotensin II type 1 receptor blocker) test in PA patient. This
interaction mechanism, in term, could further explain the interaction of KKS and RAAS.