Kanagawa Combination Anti-hypertensive Therapy (K-CAT)

• Status: Completed
• Trial end date: 2010-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the effect and safety of the antihypertensive combination therapies between losartan/amlodipine and fixed dose drug of losartan/hydrochlorothiazide.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yokohama City University Medical Center
• Treatments: Amlodipine; Diuretics; Hydrochlorothiazide; Losartan

Criteria

Inclusion Criteria:

• Under treatment of hypertension with ARB monotherapy for more than one month.

• systolic blood pressure more than 140mmHg and less than 160mmHg or diastolic blood pressure more than 90mmHg and less than 100mmHg in sitting position.

• In diabetic or CKD patients, systolic blood pressure more than 130mmHg and less than 160mmHg or diastolic blood pressure more than 80mmHg and less than 100mmHg in sitting position.

Exclusion Criteria:

• uncontrolled hypertension (diastolic blood pressure >120mmHg)

• uncontrolled diabetes mellitus (HbA1c>9.0%)

• Acute myocardial infarction, stroke and other cardiovascular events within six months

• The history of gout, or uric acid>8.0mg/dl

• Serum creatinine>2.0mg/dl

• sever liver dysfunction

• Bilateral renovascular stenosis

• secondary hypertension

• malignant hypertension

• uncontrolled arrhythmia

• pregnancy or possibility of pregnancy

• hypersensitivity to trial drug