KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine

• Status: Not yet recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

S-ketamine is often administered as a part of multimodal analgesia to reduce postoperative pain and postoperative opioid consumption. Current data indicates that ketamine may be useful for patients with prior use of opioids whereas the benefit for opioid-naive patients is less clear. However, different opioids have variable pharmacokinetic characteristics. Therefore, it is important to evaluate S-ketamine's effect on the pharmacokinetics of opioids.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Elina Brinck
• Treatments: Esketamine; Ketamine

Criteria

Inclusion Criteria:

• written informed consent

• age 18-45 years

• healthy

• Normal values in the following laboratory assessments: Hb, P-ALAT, P-AFOS, P-GT, P-creatinine, P-K, P-Na, chemical sample for urine (U-KemSeul). Pregnancy test (P-hCG-tot) must be negative.

• Urine sample for detection of any illegal drugs must be negative (U-Huum-PS)

• Normal EKG

• Normal blood pressure

• No prior use of illicit drugs

Exclusion Criteria:

• Tendency/predisposition to illicit drug use, illicit drug use in history

• Abnormal EKG

• smoking

• use of oral contraceptives

• pregnancy, lactation

• participating in a less tha 3 months ago

• Blood donation less than 3 months ago

• The subject's peripheral veins are hardly visible (predisposing difficulties in cannulation)

• weight less than 50 kg, body mass index (BMI) less than 18,5 or over 30