KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
S-ketamine is often administered as a part of multimodal analgesia to reduce postoperative
pain and postoperative opioid consumption. Current data indicates that ketamine may be useful
for patients with prior use of opioids whereas the benefit for opioid-naive patients is less
clear. However, different opioids have variable pharmacokinetic characteristics. Therefore,
it is important to evaluate S-ketamine's effect on the pharmacokinetics of opioids.