Ketamine Compared to Propofol for Pediatric GI Endoscopy
Status:
Completed
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
Elective outpatient endoscopy for children can be safely performed under general anesthesia
with either propofol (1) or ketamine (2) infusions. Both infusions have an advantage over
general anesthesia with volatile agents because they do not require intubation. The goal of
both infusions is to have the patient breath spontaneously without reacting to the endoscopy
which is a noxious stimulus. Patient movement, stridor and vomiting are can interrupt the
procedure and increase overall OR time. Propofol also carries the added risk of causing
apnea. This side effect is not commonly seen with Ketamine. Our hypothesis is that Ketamine's
profile makes it a superior drug to Propofol for elective outpatient endoscopy because of
reduced profound intra-operative interruptions and faster recovery time. We plan a study of
pediatric patients ages 1 to 10 years old undergoing elective outpatient endoscopy. The
patients will be randomized to receiving either a Ketamine or Propofol infusion, and the
intra-operative interruptions will be documented by the anesthesiologist. The Post Anesthetic
Care Unit (PACU) time to recovery will be monitored and recorded by a third party.
Details
Lead Sponsor:
State University of New York - Upstate Medical University