Ketamine Effect on Isoflurane Anesthesia

• Status: Completed
• Trial end date: 2017-11-25
• Target enrollment: 0
• Participant gender: All

Summary

Ketamine effect on isoflurane anesthesia This study is designed to study the effect of ketamine on isoflurane anesthesia. As both drugs are hypnotic and are used to cause sleep during surgery and other painful procedures, it was long believed that the actions of two drugs add to each other. For example if a man received both drugs, this man will become awake from anesthesia much later than if this man was given either of them alone.

However recent studies showed that this is not the case and ketamine can cause fast recovery from hypnotic effects of isoflurane. This was confirmed in animals.

The aim of current study is to investigate if this effect applies for humans, using a state of art brain monitoring device in wide use nowadays called BIS or bispectral index. This device can also shed some light on how ketamine can cause, if any, fast recovery from isoflurane anesthesia. Simply, by studying electrical wave coming from brain to head skin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Minia University
• Treatments: Anesthetics; Isoflurane; Ketamine

Criteria

Inclusion Criteria:

• Consent: patient must be legally fit to consent. Informed consent will be get from each patient.

• ASA status: I or II.

• Fully conscious at time of induction of anesthesia.

• No history of side effects related to any drugs used in the study.

• Planned surgery can be performed under spinal anesthesia

Exclusion Criteria:

• Incompetence: failure to give informed consent or refusal.

• Neurological or psychiatric disorders

• Addiction

• Recent intake of drugs affecting central nervous system

• ASA state more than II

• Morbid obesity

• Surgery cannot solely performed under spinal anesthesia

• Contraindication to spinal anesthesia as coagulopathy