Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

• Status: Completed
• Trial end date: 2018-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the effectiveness of ketamine infusions in the management of acute pain resulting from broken ribs suffered following a blunt trauma. Half of patients will receive the institutional standard of care and a placebo infusion (no active medication). The other half of patients will receive the institutional standard of care and a ketamine infusion. All subjects and staff will be blinded as to whether they are receiving placebo or ketamine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical College of Wisconsin
• Treatments: Acetaminophen; Analgesics, Opioid; Ibuprofen; Ketamine; Methocarbamol; Narcotics; Pantoprazole

Criteria

Inclusion Criteria:

1. age greater than 18 years

2. rib fractures following recent trauma with admission to Froedtert Memorial Lutheran Hospital

Exclusion Criteria:

1. history of adverse reaction / intolerance to ketamine therapy

2. elevated intracranial pressure

3. ischemic heart disease defined as active acute coronary syndrome

4. severe, poorly controlled hypertension (Systolic Blood Pressure > 200 mmHg or Diastolic Blood Pressure > 100 mmHg)

5. current opiate agonist/antagonist therapy

6. concurrent use of monoamine oxidase inhibitors (MAOIs)

7. chronic pain or opioid tolerance defined as > 3 weeks of >30mg oral morphine equivalents per day

8. current substance abuse with opiates (prescription and/or heroin) or ketamine

9. Glasgow Coma Scale <13

10. Intubation on arrival or need for urgent intubation on arrival

11. inability to delineate pain and/or appropriately communicate with staff

12. history of psychosis

13. three or more psychotropic medications

14. active delirium

15. glaucoma

16. pregnancy

17. prisoners